Marcus Smith starts at fly-half for Wales and Ellis Genge is the starting captain for England.
On Saturday, Ellis Genge will lead England as captain and Marcus Smith will start at fly-half as they take on Wales in Cardiff.
Smith, 24, is reunited with his Harlequins teammate and scrum-half Danny Care, who he last played with in England’s 53-10 Six Nations loss to France.
While Theo Dan and Tom Willis are on the bench, Tom Pearson makes his debut at winger.
Only Max Malins remains from the Premiership championship game’s starting lineup.
This will be the last game for the team before head coach Steve Borthwick announces his final World Cup roster on Monday morning.
After winning the Premiership with Saracens against Sale, regular captain Owen Farrell and other veterans Jamie George and Maro Itoje are not in the team.
The starting lineup from the Six Nations championship game against Ireland has been reduced to only five players. David Ribbans and George Martin are now in the second row, with Genge at prop, Jamie Blamire at hooker for Newcastle, and Will Stuart for Bath.
Lewis Ludlam and Alex Dombrandt, both regulars in the starting lineup, were joined by rookie Pearson in the back row for the match against Ireland.
Backs Guy Porter (Leicester) and Joe Marchant (Stade Francais) form a new central partnership, while Bath’s Joe Cokanasiga (wing) is back in the lineup.
Full-back Even though he received a red card against Ireland, Freddie Steward is still in the starting lineup.