Shoaib Bashir, Tom Hartley, and Gus Atkinson get their first Test caps for India against England.
Bashir has only appeared in six first-class matches since making his debut in June.
Gus Atkinson of Surrey and Tom Hartley of Lancashire, both of whom have represented England in white-ball cricket but are uncapped at Test level, are also selected.
The first Test begins on January 25 in Hyderabad.
Following injury, batter and vice-captain Ollie Pope, as well as left-arm spinner Jack Leach, return to the squad.